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Three studies compared several dosage levels of WS extract with placebos using versions of the Hamilton Anxiety Scale, with two demonstrating significant benefit of WS versus placebo, and the third demonstrating beneficial effects that approached but did not achieve significance (p=0.05).
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Sixty-two abstracts were screened five human trials met inclusion criteria. Number and results of studies identified in the review.
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The study team members applied inclusion criteria while screening the records by abstract review. Inclusion criteria were human randomized controlled trials with a treatment arm that included WS as a remedy for anxiety or stress. Search terms included "ashwagandha," "Withania somnifera," and terms related to anxiety and stress. Additionally, the reference lists of studies identified in these databases were searched by a research assistant, and queries were conducted in the AYUSH Research Portal. Systematic review of the literature, with searches conducted in PubMed, SCOPUS, CINAHL, and Google Scholar by a medical librarian. To assess existing reported human trials of Withania somnifera (WS common name, ashwagandha) for the treatment of anxiety.
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